Slavery and the slave trade had a significant effect on America including North and South America as well as the Caribbean. First of all, it gave America the required labor force for the cultivation of crops that were in high demand in Europe and other nations. In Brazil, the African slaves came to be imported when the Natives failed to fulfill the demand for labor in sugar fields. The Native Americans were falling sick because of the European diseases and the colonists realized they were not strong enough to work on fields.